Reduction in Pathogenicity in Yeast-like Fungi by Farnesol in Quail Model

Candida albicans was the first eukaryotic microorganism to exhibit quorum-sensing through the secretion of the sesquiterpene E, farnesol. This molecule is generated by dephosphorylation of farnesyl pyrophosphate in the mevalonate biosynthetic pathway in mammalian and yeast cells. Exogenous farnesol inhibits yeast-to-hyphal formation in a concentration-and time-dependent manner at the earliest stage of hyphal development. Much research has been devoted to studying the role of farnesol as an inhibitor of hyphal morphogenesis; however, little research has been published regarding the in vivo impacts of farnesol on fungal virulence and the development of Candida infection. While other studies have examined the impact of multiple doses of farnesol in addition to antimycotics, we hypothesize that C. albicans treated with a single dose of this quorum-sensing molecule could reduce fungal virulence in a quail model. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Авторы
Журнал
Издательство
MDPI
Номер выпуска
4
Язык
Английский
Статус
Опубликовано
Номер
489
Том
12
Год
2022
Организации
  • 1 Department of Microbiology and Virology, Institute of Medicine, Peoples’ Friendship, University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 2 Department of Veterinary Medicine, Moscow State University of Food Production, Moscow, 117198, Russian Federation
  • 3 Department of Biochemistry, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 4 Department of Veterinary Medicine, Agrarian Technological Institute, Peoples’ Friendship, University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 5 Department of General Pharmaceutical and Biomedical Technologies, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 6 Department of Foreign Languages, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Ключевые слова
Candida albicans; Farnesol; Quail model; Quorum sensing (QS); Virulence
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