Iron deficiency in Russia heart failure patients. Observational cross-sectional multicenter study

Aim    To evaluate the prevalence of iron deficiency (ID) in Russian patients with heart failure (HF).Material and methods    Iron metabolism variables were studied in 498 (198 women, 300 men) patients with HF. Data were evaluated at admission for HF (97 %) or during an outpatient visit (3 %). ID was determined according to the European Society of Cardiology Guidelines.Results    83.1 % of patients had ID; only 43.5 % of patients with ID had anemia. Patients with ID were older: 70.0 [63.0;79.0] vs. 66.0 years [57.0;75.2] (p=0.009). The number of patients with ID increased in parallel with the increase in HF functional class (FC). Among patients with ID, fewer people were past or current alcohol users (p=0.002), and a greater number of patients had atrial fibrillation (60.1 vs. 45.2 %, p=0.016). A multiple logistic regression showed that more severe HF (HF FC) was associated with a higher incidence of ID detection, whereas past alcohol use was associated with less pronounced ID. An increase in N-terminal pro-brain natriuretic peptide (NT-proBNP) by 100 pg/ml was associated with an increased likelihood of ID (odds ratio, 1.006, 95 % confidence interval: 1.002-1.011, p=0.0152).Conclusion    The incidence rate of HF patients is high in the Russian Federation (83.1 %). Only 43.5 % of these patients had anemia. The prevalence of ID in the study population increased with increases in HF FC and NT-proBNP.

Авторы
Mareev V.Y. 1 , Begrambekova Y.L.1 , Mareev Y.V.3 , Kobalava Z.D. 4 , Karapetyan L.V. 4 , Galochkin S.A. 4 , Kazakhmedov E.R. 4 , Lapshin A.A. 4 , Garganeeva A.A.6 , Kuzheleva E.A.6 , Efremushkina A.А.7 , Kiseleva E.V. 8 , Barbarash O.L.9 , Pecherina T.B.9 , Galyavich A.S. 10 , Galeeva Z.M.10 , Baleeva L.V.10 , Koziolova N.A. 11 , Veklich A.S.11 , Duplyakov D.V.12 , Maksimova M.N.13 , Yakushin S.S.14 , Smirnova E.A. 14 , Sedykh E.V.14 , Shaposhnik I.I.16 , Makarova N.A.16 , Zemlyanukhina A.A.17 , Skibitsky V.V. 18 , Fendrikova A.V.18 , Skibitsky A.V.18 , Spiropulos N.A.19 , Seredenina E.M.1 , Orlova Y.A.1 , Eruslanova K.A.20 , Kotovskaya Y.V. 20 , Tkacheva O.N. 20 , Fedin M.A.21
Журнал
КАРДИОЛОГИЯ
Издательство
KlinMed Consulting
Номер выпуска
5
Язык
Русский
Страницы
4-8
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.18087/CARDIO.2022.5.N2083
Том
62
Год
2022
Организации
  • 1 Medical Research and Educational Center, Lomonosov Moscow State University
  • 2 School of Fundamental Medicine, Lomonosov Moscow State University
  • 3 National Medical Research Center for Therapy and Preventive Medicine
  • 4 People's Friendship University of Russia
  • 5 Vinogradov Municipal Clinical Hospital
  • 6 Research Institute of Cardiology, Tomsk National Research Medical Center
  • 7 Altai State Medical University
  • 8 Altai Territory Cardiological Center
  • 9 Research Institute for Complex Problems of Cardiovascular Diseases
  • 10 Kazan State Medical University
  • 11 Academician Vagner Perm State Medical University
  • 12 Research Institute of Cardiology, Samara State Medical University
  • 13 Polyakov Samara Regional Clinical Cardiology Dispensary
  • 14 Academician Pavlov Ryazan State Medical University
  • 15 Ryazan Regional Clinical Cardiology Dispensary
  • 16 South Ural State Medical University
  • 17 Chelyabinsk Municipal Clinical Hospital #1
  • 18 Kuban State Medical University
  • 19 Clinical Hospital for Emergency Care
  • 20 Russian Gerintology Research and Clinical Centre, Russian Federation
  • 21 Russian Gerintology Research and Clinical Centre
  • 22 Pirogov Russian National Research Medical University
Ключевые слова
biological marker; brain natriuretic peptide; peptide fragment; atrial fibrillation; clinical trial; complication; cross-sectional study; female; heart failure; hospitalization; human; male; multicenter study; Atrial Fibrillation; Biomarkers; Cross-Sectional Studies; Female; Heart Failure; Hospitalization; Humans; Iron Deficiencies; Male; Natriuretic Peptide, Brain; Peptide Fragments
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