Possible Applications of Saccharomyces boulardii in Space Medicine

Abstract: During space flight, the astronaut’s body is continuously exposed to various stress factors which can have a negative impact on the health and working capacity. The yeast S. boulardii has pronounced probiotic, immunostimulating, anti-inflammatory, antitoxic properties that contribute to the rapid restoration of normal intestinal microbiota and the destruction of pathogenic microorganisms at an early stage. The aim of this work was to study the cell viability and mutability of probiotic Saccharomycesboulardii strains under the action of high-energy protons in doses of 5–20 Gy. Experiments demonstrated normal growth at 37°C, radioresistance and low mutation level of probiotic strains. So, preparations of S. boulardii are perspective for solution of health problems of astronauts and for study their probiotic and radioprotective properties during space flight. © 2022, Pleiades Publishing, Ltd.