Background: Burnout is a consequence of chronic occupational stress exposure. Psychiatrists are prone to burnout due to specific work-related factors. This study examined the burnout prevalence among psychiatrists. Methods: The study protocol was registered in PROSPERO (CRD42020204615). We searched MEDLINE, EMBASE, CENTRAL, PsycINFO, Web of Science, ClinicalTrials.gov, and OpenGrey for relevant publications. Random-effect meta-analysis was performed. We used subgroup analysis and meta-regression to reveal any association of geographical region, survey year, participants' age, gender, and response rate with burnout. Results: Thirty-six studies involving 5481 participants were included. The prevalence of overall burnout was 25.9% [11.1%–40.7%] as measured by a Maslach Burnout Inventory (MBI) and 50.3% [30.9%–69.8%] as measured by a Copenhagen Burnout Inventory (CBI). The pooled prevalence was 43.5% [27.9%–59%] for high emotional exhaustion (EE), 28.2% [17.5%–38.9%] for high depersonalization (DP), and 32.4% [3.4%–61.3%] for low personal accomplishment (PA). The mean scores of 22-item MBI subscales were 21.51 [18.64%–24.38%] for EE, 6.57 [5.53%–7.62%] for DP, and 31.83 [25.73%–37.94%] for PA. European psychiatrists revealed (p = 0.045) lower EE score (20.82; 95% CI 7.24–24.41) measured by 22-item MBI compared to their non-European colleagues (24.99; 95% CI 23.05–26.94). Other results include mean scores for 16-item MBI-General Survey, burnout rates, and scores in CBI subscales. Limitations: The main limitation was high heterogeneity in terms of statistics, screening methods, burnout definitions, and cut-off points utilized in included studies. Conclusions: Burnout is highly prevalent among psychiatrists. Future research should focus on finding consensus on burnout screening, longitudinal evaluation of psychiatrists' burnout predictors, and development of effective intervention strategies. © 2022 Elsevier B.V.