The positive transformation of the phenotype, the functional activity of neutrophilic granulocytes in children with recurrent respiratory infections as treatment' results of interferon and immunomodulation therapy

The present study showed the presence of the negative transformation of phenotype and defects of phagocytic function of neutrophil granulocytes (NG) in immunocompromised children with recurrent acute respiratory viral infections (ARVI), associated with different herpes viral infections (HVI) and chronic diseases of upper respiratory tract (CDURT). Prolonged and adequate interferon' therapy in combination with immunomodulatory therapy had demonstrated a high clinical efficacy, accompanied the reorganization of the base functions of NG: the positive transformation of the membrane expression of the functionally significant receptors CD64, CD32, CD16, CD11b and the modulation of the defective phagocytic activity to normal activity.