Constant growth of incidence rate of bladder cancer (BC) requires refinement of methods of early diagnostics and development of efficient treatment methods. Diagnostics and adjuvant photodynamic therapy (PDT) with the use of light and photosensitizer drugs (PD) of surface transitional cell (STC) BC are not sufficiently investigated. 40 persons aged 23 - 87 suffering from STC BC took part in the research and were subjected to complex therapy (CT). STC BC patients of this group before the transurethral resection (TUR) were administered intravenously with PD, then photodynamic diagnostics (PDD) of disease focuses was performed. Control group consisted of 15 patients with BC of the same age category, for treatment of which only TUR was used. It was established that the use of CT for STC BC contributed to decrease of relapse rate and progression of disease, increase of specific survival and quality of life of patients.