In the article the evaluation issues of the effect of the exogenous glucosamine hydrochloride and chondroitin sulfate on biochemical indices of the blood serum as well as of the parodentium tissues by the experimental inflammation are examined. The experimental model of gingivitis has been formed in 40 white rats of the Wistar line presenting the control and the main groups; additionally, the parodentium of 20 intact animals has been studied. It has been revealed that the usage of glucosamine hydrochloride and chondroitin sulfate by the experimental inflammation of the parodentium tissues leads to the normalization of the main inflammation indices including the general proteolytic activity and the activity of the acid phosphatase as well which indicates the anti-inflammatory and the parodentium protective effects.