Analysis of the world literature shows that sexual dysfunction is a common problem in patients with chronic kidney disease, both men and women, and this problem for known reasons has not received proper recognition and attention among health professionals and organizers. The prevalence of erectile dysfunction among men with chronic kidney failure ranges from 70 to 86 %. Sexual disorders are associated with uremic effects, comorbidities, anemia, hormonal disorders, autonomic neuropathy, vascular disorders, hyperparathyroidism, hyperprolactinemia, drug side effects, and psychosocial factors. Erectile dysfunction has a serious impact on the quality of life and this strongly affects the social and family life of affected patients. Sexual dysfunction is more common in men and women with chronic kidney disease and cardiovascular disease. Patients on hemodialysis have better sexual function than those without it. Sexual dysfunction has a negative impact on the quality of life of patients with chronic kidney disease and therefore they need high-quality therapy, taking into account the stage, desire and ability of patients. © 2021 ABC-press Publishing House. All right reserved.