Plasma calcifedol concentration as a marker of Vitamin D deficiency in newborns with congenital malformations [Концентрация кальцифедола в плазме крови как маркер дефицита витамина D у новорожденных с врожденными пороками развития]

The objective: to study the concentration of 25(OH)D3 in newborns of St. Petersburg depending on the presence of congenital malformations (CM). Subjects and methods. 60 newborns were examined, their gestational age made 39.4 (38-41) weeks. Children were divided into 2 groups: Group 1 - healthy children, Group 2 - children with CM. Results. Regardless of the presence of CM, the calcifedol plasma concentration was below 15 ng/ml. It was found that children with CM whose plasma calcifedol concentration was below 8.0 ng/ml needed long-term invasive mechanical ventilation (80.0 vs 40.0 hours; p < 0.005) and longer treatment in ICU (7.0 vs 4.0; p < 0,002). Negative correlations were revealed between calcifedol concentration, duration of narcotic analgesics administration (R = -044; p = 0.01), duration of mechanical ventilation (R = -049; p = 0.003) and stay in ICU (R = -0.54; p = 0.001). Conclusion. The most pronounced defciency of calcifedol was in children with severe CM requiring long-term treatment in ICU. © 2021 Serbian Chemical Society. All rights reserved.