Aesthetic treatments of the chin and jawline are becoming increasingly popular nowadays since special attention has been paid to the harmony of the lower face. One of the most used fillers in this facial area is VYC-25L. This filler has an extensive evidence base obtained during the non-clinical and clinical trials. After that many clinics around the world, including Russian ones, have started successful use of this product. However, despite the scientific evidence, aesthetic practitioners should be guided by approaches for the treatments with VYC-25L in different categories of patients. The presented article describes in detail the practical recommendations for aesthetic treatments with VYC-25L, considering the accumulated data of clinical trials and practical experience. These recommendations will be useful for cosmetologists and plastic surgeons for more effective and safe aesthetic treatments. © 2021, Media Sphera Publishing Group. All rights reserved.