A comprehensive analysis of unfavorable exogenous-social and endogenous-biological risk factors affecting the health makes it possible to determine their contribution to morbidity in the rural population under conditions of significant loads of mineral fertilizers. Objective. To determine the main exogenous-social and endogenous-biological risk factors that contribute to the dermatological morbidity, and to analyze the concomitant pathology of the population living in rural areas. Material and methods. Objects of the study - 91 out of 680 respondents with skin disease established by a doctor. The studies were carried out on the territory of Bostanlyk (fruit and vegetable) and Chinaz (cotton-growing) rural areas of the Tashkent region of the Republic of Uzbekistan. Results. When conducting a comparative assessment of social and hygienic living conditions, sanitary and hygienic working conditions, medical and biological factors and lifestyle of the rural population of the cotton-growing (main) and horticultural (control) districts of Tashkent region, statistically significant differences were revealed, criteria for identifying the contingent of the high-risk group were determined, and likelihood prognosis of dermatological pathology is given. Conclusion. The contingent of the high-risk group for dermatological morbidity was formed consistently, mainly due to such factors as professional activities related to agriculture, low level of physical activity, the presence of concomitant chronic diseases, irrational organization of recreation, non-use of personal protective equipment, unfavorable living conditions, low educational level, burdened dermatological history, working age, unfavorable working conditions, female gender, low level of medical care, underwear and clothes made of unnatural types of fabric. © 2021, Media Sphera Publishing Group. All rights reserved.