Objective. To assess the effectiveness and safety of the SMART LIFTING protocol using a combination of hyaluronic acid fillers with different characteristics in different facial zones. Material and methods. A retrospective analysis of data on 32 patients who underwent complex face correction using hyaluronic acid fillers. The participants underwent lateral lifting, which included treatment with fillers of the zygomatic, temporal, submalar and preauricular areas, chin, jawline, and central facial zones including the infraorbital area and nasolabial folds. Results. The main advantage of the SMART LIFTING protocol is lifting and rejuvenation giving a natural look. It was possible to obtain an optical redistribution of facial volumes, lifting, and harmonization of the middle and the lower face, and improvement of the periorbital area, nasolabial folds, and marionette lines. Almost all patients (93.75%) noted a pronounced improvement of score on the Global Aesthetic Improvement Scale (GAIS). Conclusion. The “SMART LIFTING” protocol makes it possible to perform complex face correction with hyaluronic acid fillers within one procedure. Lifting of the face with natural appearance, using appropriate amounts of fillers and safe correction techniques allows the doctor to use the SMART LIFTING protocol in everyday clinical practice. © 2021, Media Sphera Publishing Group. All rights reserved.