We report on the application of the U-Th-He method for the direct dating of pyrite from the alteration halo of the Novogodnee-Monto Au-Fe-skarn deposit, Polar Urals. The deposit is genetically related to the formation of volcanogenic complexes of the Ural Paleozoic belt. A modification of the original methodology for measuring U, Th and He isotopes in a single grain allowed us to determine a U-Th-He age of 382 ± 8 Ma (2σ) based on six pyrite samples from the altered rocks of the deposit (U mass fraction ~0.2 mg/kg; Th/U ~ 3.5;4He specific volume ~ 10−5 cm3·STP·g−1). This age is consistent with estimates of the age of ore formation and coeval with the end of the period of island arc magmatic activity. Our results indicate that U-Th-He dating for pyrite samples of ~1 mg in weight from the hydrothermal-metasomatic halo of ore bodies is possible, providing a crucial next step in the development of U-Th-He pyrite geochronology. © 2021 by the author. Licensee MDPI, Basel, Switzerland.