Mathematical formula for predicting the phenotype of comorbidity - Erosive-ulcerative lesions of the gastroduodenal zone and arterial hypertension in railway workers [Математическая формула прогноза фенотипа коморбидности - эрозивно-язвенных поражений гастродуоденальной зоны и артериальной гипертонии у работников железнодорожного транспорта]

Background. Diseases of the gastrointestinal tract and arterial hypertension (AH) are among the diseases with a high frequency of spread. Their combination is often considered as a comorbid pathology, especially in a population that has an increased risk of their development. Aims: to study the clinical and laboratory features of the formation of a combination of erosive-ulcerative lesions of the gastroduodenal zone in patients with arterial hypertension and to develop a method for predicting the likelihood of this comorbidity. Methods: employees were Examined (n=127, male 100%). locomotive crews art. Perm-II of the Sverdlovsk branch of Russian Railways with more than 10 years of experience. Methods of examination included analysis of anamnesis data, physical, laboratory and instrumental examinations of patients. Laboratory tests of General blood analysis were performed on a 3-diff hematological analyzer V-Counter (“West-Medica”, Austria). Traditional biochemical parameters were determined in the blood serum, as well as the concentration of individual proteins: endlotelin-1 (ET-1), monocyte chemotactic protein-1 (MCP-1) and C-reactive protein (hs-CRP). Statistical processing of the obtained data was performed on a PC using the built-in analysis package of the Excel® 2016 MSO table processor (© Microsoft, 2016), the author's (©V. S. Sheludko, 2001-2016) package of applied spreadsheets (ppet) “Stat2015” Results: the diagnostic value of a number of studied indicators was Established: the concentration of plasma proteins ET-1 and MSR-1; the level of glucose and cholesterol, as well as the content of white blood cells and platelets for the diagnosis of comorbidity: erosive and ulcerative lesions of the gastroduodenal system in patients with arterial hypertension. The obtained data allowed us to develop a mathematical formula for calculating the risk of erosive and ulcerative lesions of the gastroduodenal system in patients with arterial hypertension Conclusion: employees of locomotive crews have an increased risk of comorbid pathology-erosive and ulcerative lesions of the gastroduodenal zone in patients with arterial hypertension, which is accompanied by changes in a number of laboratory parameters. The most important of them are: the developed equation using the content of MSR-1 and endothelin-1, glucose and cholesterol, as well as the number of platelets and leukocytes in peripheral blood. Allows you to predict the risk of comorbid pathology. © 2020 Global Media Tekhnologii. All rights reserved.