The rocket-and-space branch in Russia includes about one hundred enterprises, most of which are successors of Soviet space industry. In the 90-s the branch faced serious economic problems, in the 2000-s the economic situation changed, and the branch started developing again. But it still has some problems, such as obsolescent production assets, low workload of the enterprises, low quality control and a lack of professional employees. The article is devoted to the development of an information analytical system for the rocket-and-space branch, that will help to solve almost all current problems. The authors analyze the information analytical system structure, its databases, communication and a mathematical simulation that can be used for inter-company cooperation effectiveness assessment. © 2021, Univelt Inc. All rights reserved.