Mitochondrial activity of cancer and normal mesenchymal stem cells in vitro cultured in medium with different deuterium content

We showed that cancer and normal mesenchymal stem/stromal (MSC) cells in vitro in a deuterated growth medium show a decrease of mitochondrial activity (MA), while in a deuterium-depleted medium an increase. This was established using mitotracker and rhodamine 123, and was also confirmed by expression of the UCP1 gene. The correlation dependence of mitochondrial activity in a medium with a changed ratio of deuterium/protium (D/H) and supramolecular structures was established, using the laser diffraction method. Density inhomogeneities in the deuterated medium are noted to be large, and in the deuterium-depleted medium small, in comparison with the control.

Авторы
Zlatskiy I. 1, 2 , Antipova N. 1, 3 , Zlatska A.2, 4 , Dolenko S.5 , Syroeshkin A. 1
Сборник материалов конференции
Издательство
E D P SCIENCES
Язык
Английский
Статус
Опубликовано
Номер
02005
Том
22
Год
2020
Организации
  • 1 Peoples Friendship Univ Russia RUDN Univ, Miklukho Maklaya Str 6, Moscow 117198, Russia
  • 2 NAMS Ukraine, State Inst Genet & Regenerat Med, Vyshhorodska Str 67, UA-04114 Kiev, Ukraine
  • 3 RAS, Shemyakin Ovchinnikov Inst Bioorgan Chem, Miklukho Maklaya Str 16-10, Moscow 117997, Russia
  • 4 Med Co Ilaya, Biotechnol Lab Ilaya Regenerat, UA-03115 Kiev, Ukraine
  • 5 NAS Ukraine, Inst Colloid & Water Chem, Akademika Vernadskoho Blvd 42, UA-03142 Kiev, Ukraine
Дата создания
20.04.2021
Дата изменения
20.04.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/73177/
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