Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings

Six novel phane-structured diazacrowns containing γ-piperidone and pyridine rings were synthesized from podand 2-+,6-bis(2-formylphenoxymethyl)pyridine, with the γ-piperidone moiety having been constructed in the course of its domino condensation with simple ketones and ammonium acetate. The compounds were tested in vitro for antimicrobial and cytotoxic activity against four human cancer cell lines (Hep-G2, RD, MCF-7, Lu-1) and the Vero cell line. X-Ray structure study of one representative compound revealed its rac-1RS,23SR,24RS,26SR configuration. © 2020

Авторы
Nguyen L.M.1, 2 , Truong H.H. 3 , Khrustalev V.N. 3, 4 , Truong S.T.1 , Nguyen D.T. 1 , Tran V.T.T.1 , Mai S.T.1 , Tran V.T.1 , Le A.T. 1
Журнал
Mendeleev Communications
Издательство
Royal Society of Chemistry
Номер выпуска
6
Язык
Английский
Страницы
753-755
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1016/J.MENCOM.2020.11.021
Том
30
Год
2020
Организации
  • 1 Faculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, 100000, Viet Nam
  • 2 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Viet Nam
  • 3 Faculty of Science, Peoples Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 4 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Ключевые слова
antimicrobial; cytotoxicity; diazacrownophane; domino condensation; pyridine; γ-piperidone
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