RUSSIAN LEGISLATION ON LOCAL SELF-GOVERNMENT [LA LEGISLACIÓN RUSA SOBRE EL AUTOGOBIERNO LOCAL]
Статья
Revista Derecho del Estado.
Universidad Externado de Colombia.
2020.
С. 243-271
The development of a rapid and diverse access to complex natural product-like 3,4-fused indole scaffolds has always attracted considerable attention from synthetic and medicinal communities. We herein disclose a modular and straightforward protocol to prepare the densely substituted polycyclic azepino[5,4,3-cd]indole scaffolds. This synthetic process involves an Ugi four-component reaction from easily available starting materials and a gold-catalyzed post-Ugi domino dearomatization/Michael addition sequence, enabling facile access to the highly functionalized azepino[5,4,3-cd]indole core with excellent chemo-, regio-, and diastereoselectivity. © 2020 American Chemical Society. All rights reserved.