In this paper there have been analyzed problems of biodiversity conservation in the Altai Republic in the context of economic development of the territory. The main types of economic activities have a different impact on the biodiversity of the region. The authorities and environmental services take measures to preserve the natural environment, flora and fauna, including the organization of specially protected natural areas, the study of biodiversity and the publication of regional Red Data Books, the elaboration of projects for the artificial cultivation and breeding of certain species of plants and animals, including the Red Data Book ones. It has been shown that the problem of preserving medicinal plants included in the Red Data Book of the Altai Republic has been unsolved for more than 20 years. This can lead to the almost complete disappearance of these species outside the borderlines of specially protected natural areas of the federal level. © Published under licence by IOP Publishing Ltd.