The aim of the study is a possibility justification of the functional state correction of students in the learning environment through development of adaptive behavior skills in stress and increase of subjective evaluation of life quality. Methods: research and analysis of cardiac rhythm variability parameters, functional state of the central nervous system, daily monitoring of heart rate and blood pressure, indicators of life quality associated by health condition, features of coping behavior among students of the Khanty-Mansiysk State Medical Academy (n = 96). The structure of canonical roots was identified by means of Pearson's pair correlations. The first (R1 = 0.75; p < 0.001) and second (R2 = 0.72; p = 0.004) canonical roots proved to be statistically significant. Results. The results of the canonical correlation analysis between physiological parameters and biosocial characteristics (behavior in stress and life quality self-esteem associated by health condition) were given in students of the northern medical establishment. The indicators of variation chronoreflexometry correlated to a greater extent with the choice of coping behavior; the three main styles of coping had significant factor loading (r = 0,438-r = 0,558). Parameters of variation pulsometry, mesors of heart rate and systolic blood pressure were the most correlated with life quality self-esteem among physiological parameters; the highest factor loadings were in the scales of PF ( r = 0.637) and RE (r =-0.455). Conclusion: the revealed relations substantiate the possibility of the physiological state correction in students of higher school through increasing its subjective well-being and the formation of adaptive behavior in stress. © 2018 Ekologiya Cheloveka (Human Ecology). All rights reserved.