Modern educational systems are aimed at creating an intercultural educational environment and promoting multicultural exchange. Communication and interpersonal relations are a key-tool in the development of new educational and cultural norms, therefore, psychological well-being and intercultural adaptation related to communication should receive due attention in psychological research. The article is devoted to the problem of interpersonal relations between Russian and Turkish students. The relevance of this problem is determined by the fact that interpersonal relationships are the communicative basis of modern society. The effectiveness of training and quality of students' life are largely determined by the existing interpersonal relationships in the student's team. The types of interpersonal relationships and psychological well-being of two groups of students which were analyzed by the empirical study. By means of the correlation analysis typical interrelations of the interpersonal relations and psychological well-being in groups of the Russian and Turkish students are revealed. Besides differences in the majority of indicators of interpersonal relations brought to light; in particular, the severity of authoritarianism, selfishness, aggressiveness, suspicion, friendliness, and more. It is determined that Turkish students can be characterized more prosperous psychologically compared to Russian students. These differences are deeply due to the peculiarities of mentality, culture, as well as the degree of awareness of subjective values and goals of life. The practical significance of the study lies in the possibility of using the results in the development of programs to improve the effectiveness of interpersonal relations in a multicultural educational environment.