Comprehensive studies for development of galenicals with antimicrobial activity from hypericum perforatum L. Herb

This article describes the development galenicals with antimicrobial activity from Hypericum perforatum L. herb. Based on the working hypotheses, we developed a mathematical model. Its adequacy was verified experimentally, and it was noted that the working hypotheses suggested were not disapproved. Carrying out microbiological studies, we found that the maximum level of ethanol-water extract’s antimicrobial activity was observed in the samples obtained with ethanol 72 and 97 % v/v. It was determined that the level of antimicrobial activity of ethanol-water extracts (1:5 w/v) with ethanol 72 and 97 % v/v was equal to that of reference drug «Chlorhexidine bigluconate water solution 0.05 %». It was found that using the filtration method of extraction for one hour, it is possible to obtain the liquid extract (1:1 w/v) with the concentration of dry residue that equals 13.0 ± 0.7 w/v, and in two hours, we can obtain the tincture (1:5 w/o) with the yield of main biologically active substances more than 90 %. The comprehensive studies conducted increase theoretical knowledge in the field of development of galenicals with antimicrobial activity from Hypericum perforatum L. herb. © 2019, Folium Ltd. All rights reserved.