Introduction: Respiratory syncytial viral (RSV) bronchiolitis is a severe respiratory lesion, which is often found among premature infants, but has not been sufficiently studied in this group of newborns. The aim of the study was to analyze clinical and laboratory features of the course of RSV infection in premature infants. Materials and methods. Clinical, laboratory and x-ray examination of 40 pre mature infants with RSV-bronchiolitis verified by immunofluorescence reaction and polymerase chain reaction was carried out. Research result. Among patients with RSV-bronchiolitis, children with gestational age of 29–32 and 33–35 weeks and body weight of 1000–1499 and 1500–2499 grams predominate significantly. In patients, the disease was often accompanied by a lack of temperature, symptoms of bronchial obstruction, crepitation, development of respiratory failure II–III CT in 77,5% of cases, severe need for oxygen therapy (80%), hospitalization in ORNT (50%). Conclusion. Premature infants constitute a risk group for the development of RSV bronchiolitis. © 2019 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.