Modern approaches to the diagnosis and treatment of pulmonary hypertension in children with bronchopulmonary dysplasia

In the literature review on the basis of relevant international and domestic consensus documents, recommendations developed by Pediatric Pulmonary Hypertension Network (PPHNet) in the USA and Canada in 2017, the European Pediatric Pulmonary Vascular Disease Network (EPPVDN) in 2016, and the Russian clinical guidelines in 2018, as well as authors own experience, present information on diagnostic criteria, patients at risk, clinical, echocardiographic diagnosis of pulmonary hypertension (PH) in children with bronchopulmonary dysplasia (BPD). The review provides information on the diagnostic significance of determining the brain natriuretic peptide levels, the N-terminal part of the prohormone of the brain natriuretic peptide in the diagnosis of PH in BPD, indications for cardiac catheterization and vasoreactivity testing, and other imaging methods. Information is presented on the management, immunization, and therapy of patients with BPD complicated by PH, indications for oxygen therapy, the appointment of pulmonary vasodilators (sildenafil, bosentan), treatment regimens for these drugs. © 2020, Pediatria Ltd.. All rights reserved.