Clinical experience with topical isotretinoin in the treatment of comedonal acne

Introduction. The prevalence and recurrence of acne makes it relevant to develop practical recommendations for treatment of this disease with drugs with anti-inflammatory and seborrheic activity (ointment containing 0.1 and 0.05% isotretinoin). Aim of study. Evaluation of the clinical efficacy of ointment containing isotretinoin 0.1 and 0.05% in patients with comedonal acne. Material and methods. All patients with comedonal acne (n=62) were examined with a determination of the dermatological index of acne (DIA) and the level of sebum gland production. In patients of the main group (n=42), monotherapy was performed using an ointment containing isotretinoin 0.1 and 0.05%. Patients of the comparison group (n=20) received external therapy with cream containing adapalene. The efficacy, tolerability, and duration of clinical remission were evaluated in patients with comedonal acne who applied an ointment containing 0.1 and 0.05% isotretinoin for 12 months, and in patients of the comparison group. Results. After therapy, clinical efficacy was recorded in all patients, but in the main group the results of therapy were better — 85.5% versus 78% in the comparison group. Good tolerance of therapy and a high level of compliance were noted. Conclusion. The high efficacy and tolerability of therapy when using an ointment containing isotretinoin 0.1 and 0.05% in patients with comedonal form of acne was ascertained. © 2020, Media Sphera Publishing Group. All rights reserved.