Study of the Solubility of Furazolidone from Solid Dispersions with Polyvinylpyrrolidone

Abstract: The effect of solid dispersions (SDs) on the solubility of furazolidone is studied. Furazolidone and its SDs with polyvinylpyrrolidone (PVP), PVP-10 000, PVP-12 600, and PVP-24 000 are examined. When using SDs, the solubility and dissolution rate of the nitrofuran derivative is increased. The solubility of furazolidone from SD is increased by a factor of 1.1 to 1.6. The dissolution rate of SDs is increased by a factor of 1.8 to 2.8. The complex of physicochemical methods of investigation suggests that an increase in solubility from SDs is caused by the loss of crystallinity and the formation of a solid solution of furazolidone during the preparation of SDs, as well as the solubilizing effect of the polymer during the subsequent dissolution of the SD in water. The results can be used in the development of hydrophilic soft and fast dissolving solid dosage forms of furazolidone with increased release and bioavailability. © 2020, Allerton Press, Inc.