Additive manufacturing in space is supposed to solve a problem of independently creating parts for repair, modifying scientific equipment and designing new devices by astronauts without support from the Earth. However, 3D printing in space is a challenging task, which requires a detailed study of machines, technologies and materials. This article considers the prospects of using objects from Polyamide 12, which are obtained by 3D technology-selective laser sintering (SLS), in orbits during space explorations. The major research purpose is the investigation of the anisotropy structure of the Polyamide 12 samples. The paper presents theoretical studies of SLS powder materials permeability for gases due to their high porosity. The proposed mathematical model allows calculating material permeability for gases, depending on its structure. This work describes the developed technique of the parts manufacturing from EOSPA 2200 material by 3D printer EOS Formiga P 1000. The experimental results are compared to the simulation data and discussed. © 2020, Univelt Inc. All rights reserved.