Results of study dealing with antimicrobial activity of model gel mixtures for dental use with juniper essential oil

Background: In the last decade the incidence of periodontal disease has increased many times, and, according to data from WHO, it has become a global problem. In Russia 98.5% of those examined have periodontal disease. Currently, there is a shortage of locally produced medical remedies for the treatment of periodontal diseases. This situation creates a need for their pharmaceutical development. Aim: To study the antimicrobialactivity of model gel mixtures for dental use, with juniper essential oil as the final stage, in the development of a new soft dosage form for dental use. Materials and methods: Model samples of gel with apple pectin and gel with carbomer 934 were obtained. Antimicrobial activity was determined according to GPI.1.2.4.0010.18 “Determination of the antimicrobial activity of antibiotics by agar diffusion”. Results: All samples showed an acceptable degree of antimicrobial activity, however developed gel samples turned out to be priority in comparison with the market drug. Conclusion: It was established that the developed samples have moderate and high antibacterial activity in relation to the studied microorganism strains and a more pronounced biocidal effect than the reference drug – Metrogil-Dent gel. © 2020, Advanced Scientific Research. All rights reserved.