Microwave-assisted sequential three-component synthesis of pyrrolyl-substituted chromeno[2,3-c]isoquinolin-5-amines

[Figure not available: see fulltext.] Sequential one-pot domino reaction of homophthalonitrile, salicylaldehydes, and pyrroles in basic media under MW irradiation results in the formation of novel chromeno[2,3-c]isoquinolin-5-amines. The transformation represents a domino sequence that starts with Knoevenagel condensation, followed by two nucleophilic cyclizations, consecutively forming 2-iminochromene and 5-iminoisoquinoline cycles. Michael addition of the pyrrole unit to the chromene cycle finishes the transformation. The reaction tolerates various salicylaldehydes and pyrroles, producing target molecules with good 45–67% yields. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.