Antidiabetic Biguanides as Anti-Aging Drugs

Evidence has emerged that metformin and other antidiabetic biguabides are promising candidates for pharmacological interventions leading to slowing down of aging, prolonged life span and preventing or postponing age-associate diseases, including cancer. In this chapter, the available data on effects of biguanides in rodents are summarized and discussed.

Авторы
Anisimov V.N. 1, 2, 3
Журнал
RSC Drug Discovery Series
Издательство
Royal Society of Chemistry
Номер выпуска
57
Язык
Английский
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1039/9781782626602-00416
Том
2017-January
Год
2017
Организации
  • 1 Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Leningradskaya str., 68, Pesochny-2, St. Petersburg, 197758, Russian Federation
  • 2 Institute of Cytology, The Russian Academy of Sciences, Tikhoretsky prosp. 4, St.Petersburg, 194064, Russian Federation
  • 3 People Friendship University of Russia, Miklukho-Maklay str. 6, Moscow, 117198, Russian Federation
Ключевые слова
buformin; carcinogen; metformin; phenformin; aging; amyotrophic lateral sclerosis; antiaging activity; Article; cancer inhibition; drug activity; Huntington chorea; lifespan; long term care; nonhuman; preclinical study
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