Copper-Catalyzed Multicomponent Reactions: Synthesis of Fused 1,2,3-Triazolo-1,3,6-triazonines

We describe our results on the synthesis of fused 1,2,3-triazolo-1,3,6-triazonines through a copper-catalyzed multicomponent reaction. The products were obtained in moderate to excellent yields by the reaction of 2-azidobenzaldehydes, substituted diaminobenzenes and a range of terminal alkynes in the presence of a catalytic amount of copper iodide, with Et3N as base, in DMSO at 100 °C. This method proved to be efficient for the combinatorial synthesis of new medium-sized N-heterocyclic rings with potential applications in biological studies. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim