The material presented in this paper contains data on the use of PRP (platelet rich plasma-autologous plasma enriched with platelets) in the treatment of severe forms of KCS (keratoconjunctivitis sicca) dry keratoconjunctivitis dogs'. The proposed method is based on the use of platelet growth factors contained in PRP [1]. Comparison of modern treatment regimens and regimens with the addition of PRP showed sufficient therapeutic efficacy of the latter in the treatment of dry keratoconjunctivitis of dogs and related various keratopathies. When using PRP as part of the complex therapy of KCS, treatment time is reduced, the rate of instillation of antibiotics, immunosuppressive drugs is reduced, the period of remission, which is persistent and prolonged, is increased. On the basis of changes in the cytological picture of smears, it is possible to judge the degree of the inflammatory process, the change in the level of lesoproduktsii and the level of regeneration of the cornea and conjunctiva of the eye in severe forms of KCS dogs.