POLYMORPHISMS OF GSTP1 GENE AND PATHOSPERMIA AS A MALE INFERTILITY FACTORS IN MOSCOW

Infertility affects 15% of married couples and 45-50% of cases are caused by impaired spermatogenesis. It is known that free reactive oxygen species (ROS) reduce sperm motility. Glutathione-S-transferase (GSTP1) is an important multifunctional ejaculate protein, providing protection against xenobiotic and ROS. The purpose of the research is to study the association of Ile105Val and Ala114Val polymorphisms of the GSTP1 gene with risk of pathospermia as a male infertility factor in Moscow region. Our study reveals that the 105Val (G) and 114Val (T) alleles of GSTP1 gene are the genetic risk factors for unexplained male infertility, especially in the patients with teratospermia.