Anemia occurs in horses of any age, it is not surprising that the list of possible causes, which may include an increase in red blood cell destruction, is quite high: infections, immune-mediated conditions, blood clots as well as a decrease in red blood cell production, which may be due to bone marrow diseases, kidney disease, etc. Equine infectious anemia (EIA) is a viral disease of members of the horse family, caused by an RNA-containing virus from the Lentivirus subfamily Retroviridae. It is accompanied by lesions of the blood-forming organs and is manifested by recurrent or persistent fever, anemia, and a disorder in the cardiovascular system. EIA still stands among the most important theoretical and practical problems of veterinary virology. Over the past few years, epizootic cases have been observed in the territory of the European Union (Germany, Poland, France 2015; Greece, Slovakia 2016; Germany 2017), the Russian Federation (Kemerovo Oblast, Pushkinsky District of St. Petersburg 2018), etc. Modern diagnostics EIA, represented by various serological and molecular genetic methods the only reliable way to control the disease.