ENDOGENOUS INTOXICATION SYNDROME IN CANINE CHRONIC HEPATITIS

Chronic hepatitis is a heterogeneous group of inflammatory processes in the liver followed by cirrhosis. Cytolysis of hepatocytes causes the process of necrobiosis, liver cells and the formation of pronounced endogenous intoxication. With the progression of chronic hepatitis, there is a gradual destruction of the liver parenchyma, a change in the metabolism of hepatocytes and their destruction, resulting in an endogenous intoxication syndrome. One of the indicators characterizing the intoxication severity are considered leukocyte indices, in which indicators of leukocyte formula are used. These indices allow to evaluate the workings of the immune system, as well as the level of immunological reactivity, which determines the formation of the observed adaptive response. Taking into account other hematological parameters, we can judge the severity of the pathological process and the effectiveness of the therapy.