Objective. To assess the role of polymicrobial associations in the genesis of inflammatory diseases of the female genital organs and to determine the most rational approaches to diagnosis and treatment. Material and methods. The materials of the World Health Organization, the Cochrane Society, the guidelines of leading professional societies, and clinical trials published on official websites and in open access were analyzed. Results. There was information on the frequency of female genital tract inflammatory diseases caused by microbial combinations, as well as the established facts on resistance to antimicrobial agents, recommendations for their diagnosis and treatment, by indicating the strength of the evidence and convincingness of recommendations. Conclusion. The recent changes in the epidemiology of inflammatory diseases, the prevalence of polymicrobial associations in their etiology, and the increasing microbial resistance require new approaches to the treatment and prevention of sexually transmitted infections and diseases accompanied by abnormal vaginal discharge. © 2017, Bionika Media Ltd. All rights reserved.