Synthesis of new [γ-(Aryl)pyridino]dibenzo-27,28-diazacrownophanes containing two pyridine rings

In continuation of developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyri-dine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesized successfully by one-step domino-condensation of podand 2,6-bis[(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds 5a-c were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD, FL and MCF-7). Compound 5b showing the highest cytotoxicity is interesting for the development of promising anticancer drugs. © ISUCT Publishing.