AGE-RELATED CHANGES IN CORTICAL THICKNESS OF HUMAN ARCHICEREBELLUM

Age-related changes in the thickness of the human cerebellar cortex in periods of growth and human development have not been studied enough. The article is devoted to the study of cortical thickness in the flocculonodular lobe of the cerebellum (115 cerebellums) received from human corpses of both sexes, aged from birth to 20 years. The material was grouped in annual intervals. Measurement of the cortical thickness was performed at the apex of the cerebellar folium on virtual images of sagittal paraffin sections, 10-mu m-thick, Nissl-stained. For indicators of cortical thickness in different age groups the mean, the standard error and the confidence interval were calculated. The results have shown that the main increase in the cortical thickness in human archicebelellum is observed from birth to 3 years of age. The increase in cortical thickness in the nodule and in the right flocculus is also observed by age 7-8 years, in the left flocculus - by age 15 years. Lateral asymmetry of cortical thickness in the right and left flocculus is registered in the intervals from birth to 3 years and from 9 to 11 years of age.