Introduction. The prevalence of myocardial infarction depends on various risk factors, the informativeness of which is insufficiently studied. The aim of the study was to study the Association of myocardial infarction (MI) with risk factors (FR), to determine the level of informativeness of FR for the development of a prognostic model. Material and methods. FR of MI development was studied in 155 patients with this pathology at the age of 50 to 75 years by the method of questioning and laboratory-instrumental study. The control group consisted of 127 people of the same age without THEM, examined similarly. Results. Among the studied FR in patients with THEM, arterial hypertension, hypercholesterolemia and angina pectoris were the most common. To determine the probability of its development, angina pectoris, alcohol abuse, hypercholesterolemia and hypertension are the most informative. Developed regression model to predict THEM highly informative FR. Discussion. The study of risk factors for myocardial infarction on the basis of prevalence and information allows to objectively identify the priority causes of the formation of this pathology. Conclusion. The use of the obtained data on FR and the regression model makes it possible to carry out prevention and correction of FR MORE effectively, taking into account the degree of risk. © 2019 Izdatel'stvo Meditsina. All rights reserved.