The relevance of the study is determined by growing tensions in the relations between the Russian Federation and the countries of the Western world, as well as the aggravating Russophobia and anti-Russian propaganda. One of the reasons for this is the divergence of the supreme values of these cultural and civilizational paradigms. Social and philosophical conception of the phenomenon of supreme values and differences in their meaning are important, because in the modern world, they are among the most crucial elements of the formation of national consciousness and civic identity, and, as a spiritual and social construct, can be understood using some philosophical methods with a glance to new realities of life. The article provides a social and philosophical analysis of various approaches to the understanding of the phenomenon of supreme values, their particular features in the framework of the Russian World and Western civilization historically and in the modern science. It is established that the divergences in the value orientations of the two modern global civilizations trace their origins to the contradictions of the Orthodoxy and Protestantism. It is found that in recent decades, the universal supreme values of the Western world have been undergoing a significant transformation due to the influence of postmodern ideas, while in the Russian world the traditional values continue to prevail. © 2019, Ecozone, OAIMDD. All rights reserved.