Comparison of Quantitative Analytical Techniques for Dabigatran in Blood Plasma of Humans with Knee Replacements

Two different literature methods were used to compare the experimental efficacy and accuracy of dabigatran assays in blood of 30 patients with knee replacements. Blood plasma was collected from patients who underwent anticoagulant therapy and were administered the medicine at a dose of 220 mg. Residual and peak dabigatran concentrations were determined by HPLC-MS and HPLC-MS/MS. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Авторы
Kozlov A.V. 1 , Smirnov V.V. 1 , Sychev D.A.2 , Bochkov P.O. 3 , Chistyakov V.V. 4 , Stepanova E.S. 4 , Makarenkova L.M. 4
Журнал
Pharmaceutical Chemistry Journal
Номер выпуска
8
Язык
Английский
Страницы
771-774
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1007/s11094-019-02077-x
Том
53
Год
2019
Организации
  • 1 I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russian Federation
  • 2 Russian Medical Academy of Continuous Professional Education, Ministry of Health of the RF, Moscow, 125993, Russian Federation
  • 3 V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russian Federation
  • 4 Research and Education Center, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
Ключевые слова
anticoagulant; dabigatran; HPLC; mass-spectroscopy; pharmacokinetics
Дата создания
24.12.2019
Дата изменения
24.12.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/54930/
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