Reaction of an Antioxidant (Sodium Sulfite) with 3-Hydroxy-6-Methyl-2-Ethylpyridinium Salts

The reaction of an antioxidant excipient (sodium sulfite) with 3-hydroxy-6-methyl-2-ethylpyridinium hydrochloride drug substance was studied using thermal analysis of the solid drug substances and biological testing on cell culture (Spirotox model) in aqueous solutions of various isotopic compositions. © 2015, Springer Science+Business Media New York.

Авторы
Timorovich O.V. 1 , Lyulina E.B. 1 , Pleteneva T.V. 1 , Maksimova T.V. 1 , Syroeshkin A.V. 2 , Uspenskaya E.V. 1 , Burdeinaya T.N. 3 , Shandryuk G.A.4
Журнал
Pharmaceutical Chemistry Journal
Номер выпуска
12
Язык
Английский
Страницы
840-842
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1007/S11094-015-1206-Z
Том
48
Год
2015
Организации
  • 1 Department of Pharmaceutical and Toxicological Chemistry, People’s Friendship University of Russia, 8 Miklukho-Maklaya Ul., Moscow, 117198, Russian Federation
  • 2 Institute of Applied Geophysics, 9 Rostokinskaya Ul., Moscow, 129128, Russian Federation
  • 3 Legkaya Voda Co., 1 Malaya Yushun’skaya Ul., Bldg. 1, Moscow, 117303, Russian Federation
  • 4 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
  • 5 Laboratory of Polymer Modification, 29 Leninskii Prosp., Moscow, 119991, Russian Federation
Ключевые слова
3-hydroxy-6-methyl-2-ethylpyridine; drug substance; excipient; sodium sulfite; Spirotox; thermal analysis
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