Гены и клетки.
Human Stem Cell Institute.
Том 11.
2016.
С. 43-47
Asymmetric Total Synthesis of (−)-Erogorgiaene and Its C-11 Epimer and Investigation of Their Antimycobacterial Activity
A short, nine-step, highly enantioselective synthesis of (−)-erogorgiaene and its C-11 epimer is reported. The key stereochemistry controlling steps involve catalytic asymmetric crotylation, anionic oxy-Cope rearrangement and cationic cyclisation. (−)-Erogorgiaene exhibited promising antitubercular activity against multidrug-resistant strains of Mycobacterium tuberculosis. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Авторы
Incerti-Pradillos C.A.1
,
Kabeshov M.A.1
,
O'Hora P.S.1
,
Shipilovskikh S.A.1,
2
,
Rubtsov A.E.2
,
Drobkova V.A.2
,
Balandina S.Y.2
,
Malkov A.V.
1,
3
Издательство
Wiley-VCH Verlag
Номер выпуска
40
Язык
Английский
Страницы
14390-14396
Статус
Опубликовано
Ссылка
Том
22
Год
2016
Организации
- 1 Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, United Kingdom
- 2 Department of Chemistry, Perm State University, Bukireva 15, Perm, 614990, Russian Federation
- 3 Chemistry Department, Peoples' Friendship University of Russia, Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
Ключевые слова
allylation; asymmetric catalysis; enantioselectivity; rearrangement; total synthesis
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Institut za Istrazivanja.
Том 14.
2016.
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