Objective. To restore fertility in women with tuboperitoneal infertility, by applying a comprehensive approach Subject and methods. A total of 40 women with an infertility history of 3 to 10 years were examined. In the first step of treatment, a small proportion of patients underwent reconstructive plastic surgery on the fallopian tubes (as indicated). All the women received medical therapy added by the use of hyaluronidase conjugate (longidase) in an outpatient setting. Results. The improved clinical picture of the disease in the women with tuboperitoneal infertility after a course of therapy using hyaluronidase conjugate was noted in 76% of the patients; endometrial normalization, as evidenced by ultrasonography, was seen in 62%; the conception rate was 26.5% after two therapy courses. Conclusion. Hyaluronidase conjugate exerts a pronounced adhesiolytic effect, which allows the results of treatment to be improved in women with tuboperitoneal infertility. © Bionika Media Ltd.