All kinds of technogenic activity during tens and hundreds of years to some extent lead to the transformation of local volumes of near-surface layers of the earth's crust, the formation of a specific space — the geological environment. The object of close attention in this article are arrays of rocks, which are associated with oil and gas fields in the oil and gas bearing Orenburg region. An attempt was made to investigate in detail the causes and consequences of unusual, often unpredictable events, such as the transformation of physical and chemical characteristics of groundwater, the change in the reservoir properties of blocks and layers of sedimentary, magmatic and metamorphic rocks. The changes in hydro-geodynamic and geophysical parameters of rocks that lead to the manifestation of catastrophic events — technogenic earthquakes in the most developed and often densely populated areas with a complex urban and economic infrastructure are considered. The article systematizes information about the history of geological development, the geological structure and tectonic regime of the southeast of the Volga-Urals anteclise within the Orenburg Pre-Ural region. Information is given on the types and degree of man-made loads on geological blocks and structures in connection with the development of oil and gas condensate deposits, the injection of associated formation waters and toxic industrial effluents into deep absorbing layers of carbonate rocks of the Viseisk-Bashkir aquiferous complex. To assess the state of the geological environment, the results of seismic monitoring conducted by the Department of Geoecology of the Orenburg Scientific Center of the Ural Branch of the Russian Academy of Sciences in conjunction with the industrial association for gas production “Orenburggazprom” are taken into account. The possibilities of estimating further changes in the geological environment within the region under study are considered, proceeding from the current state of technogenic and geodynamic mutual influence. © 2019, Publishing house Mining book. All rights reserved.