Ovarian cysts are one of the most common pathologies that are characteristic of cows of all ages, but more often in the second to fifth lactations, 1-4 months after calving and cause significant damage due to the increase in the interwell interval, an average of 22-64 days or more. For the treatment of cows with ovarian cysts steroid hormones are shown, serum gonadotropin preparations and to placental row, synthetic analogues of GnRH and synthetic analogs of prostaglandins. It is generally recognized that disruption of the normal endocrine balance plays a major and initial role in the development of cysts. It is proved that in the early postpartum period about 25% of cows with cysts had subluteal level peripheral blood progesterone concentrations launcher mechanism of formation of persistent follicles with further transformation into follicular cysts. Disruption of the positive feedback mechanism - 17β-estradiol-LH precedes the formation of a persistent follicle and the formation of a follicular cyst after calving. Low levels of progesterone concentration in the peripheral blood is the main symptom and initial cause of the persistence of follicles and the appearance of cysts. © 2019 Plant Archives. All rights reserved.