The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction

Background: Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation between the efficacy and safety of haloperidol and the activity of CYP3A4 in patients with alcohol abuse. Objective: The aim of this study was to evaluate the correlation between the activity of CYP2D6 and the efficacy and safety of haloperidol in patients with diagnosed alcohol abuse. Methods: The study involved 70 men (average age: 40.83±9.92 years) with alcohol addiction. A series of psychometric scales were used in the research. The activity of CYP2D6 was evaluated by high-performance liquid chromatography with mass spectrometry using the ratio of 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline to pinoline. Genotyping of CYP2D6 (1846G>A) was performed using real-time polymerase chain reaction. Results: According to results of correlation analysis, statistically significant values of Spearman correlation coefficient (rs) between the activity of CYP2D6 and the difference of points in psychometric scale were obtained in patients receiving haloperidol in injection form (Sheehan Clinical Anxiety Rating Scale =−0.721 [P<0.001] and Udvald for Kliniske Undersogelser Side Effect Rating Scale =0.692 [P<0.001]) and in those receiving haloperidol in tablet form (Covi Anxiety Scale =−0.851 [P<0.001] and Udvald for Kliniske Undersogelser Side Effect Rating Scale =0.797 [P<0.001]). Conclusion: This study demonstrated the correlations between the activity of CYP2D6 isozyme and the efficacy and safety of haloperidol in patients with alcohol addiction. © 2016 Sychev et al.

Авторы
Sychev D.A.1 , Zastrozhin M.S. 1, 2, 3 , Smirnov V.V.4 , Grishina E.A.1 , Savchenko L.M.1 , Bryun E.A.1, 2
Издательство
Dove Medical Press Ltd
Язык
Английский
Страницы
89-95
Статус
Опубликовано
Том
9
Год
2016
Организации
  • 1 Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 2 Department of Public Health, Moscow Research and Practical Centre for Narcology, Moscow, Russian Federation
  • 3 Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 4 National Research Center, Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russian Federation
Ключевые слова
Alcohol addiction; Biotransformation; CYP2D6; Haloperidol; Side effects
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