Effects of polysaccharide ginsan from Panax ginseng on liver function

Ginsan, a polysaccharide isolated from Panax ginseng, has been shown to be a potent immunomodulator, producing a variety of cytokines such as TNF-α, IL-1β, IL-2, IL-6, IL-12, IFN-γ and GM-CSF, and stimulating lymphoid cells to proliferate. In the present study, we analyzed some immune functions 1st-5th days after ginsan i.p. injection, including the level of non-protein thiols (NPSH) as antioxidants, heme oxygenase (HO) activity as a marker of oxidative stress, zoxazolamine-induced paralysis time and level of hepatic cytochrome P-450 (CYP450) as indices of drug metabolism system, and activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, and albumin level as indicators of hepatotoxicity. Ginsan in the dose of 100 mg/kg caused marked elevation (1.7-2 fold) of HO activity, decrease of total CYP450 level (by 20-34%), and prolongation of zoxazolamine-induced paralysis time (by 65-70%), and showed some differences between male and female mice. Ginsan treatment did not seem to cause hepatic injury, since serum AST, ALT, and ALP activities and levels of total bilirubin and albumin were not changed.

Авторы
Song J.-Y.1 , Akhalaia M.2 , Platonov A. 3 , Kim H.-D.1 , Jung I.-S.1 , Han Y.-S.1 , Yun Y.-S.1
Издательство
Pharmaceutical Society of Korea
Номер выпуска
5
Язык
Английский
Страницы
531-538
Статус
Опубликовано
Том
27
Год
2004
Организации
  • 1 Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAERI, 215-4, Gongneung-dong, Nowon-ku, Seoul 139-706, South Korea
  • 2 Laboratory of Radiation Biophysics, Department of Biophysics, Moscow State University, Vorobiovi Gory, 119899, Moscow, Russian Federation
  • 3 Department of Radioecology, Ecological Faculty, Peoples Friendship University of Russia, Podolskoe shosse, 8/5, 113093, Moscow, Russian Federation
Ключевые слова
Cytochrome P450; Ginsan; Heme oxygenase; Non-protein thiols; Polysaccharide
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/3637/
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