In the context of transforming economy, creating clusters is one of the attractive strategies used by agro-industrial formations. However, there is still no single system of assessment of their economic and financial performance. The purpose of this article is to consider a method for calculating these indicators within the agro-industrial cluster based on the relationships and interdependence of partner enterprises. To calculate the integral efficiency index, a sample of indicators was selected, which more fully reflect the corporate system specific nature. Integrated economic and financial efficiency of agro-industrial cluster is regarded as their interconnectedness and interdependent of business partners system for the general business tasks system implementation with ensuring of the corporate type integrated system maximum effectiveness. © 2018 Allied Academies.