The waveguide propagation of a monochromatic electromagnetic wave in a multilayer smoothly-irregular integrated dielectric structure has been studied under natural physical and mathematical assumptions. Approximate solution of the vector electrodynamic problem satisfying the condition of smoothly varying shape of the structure is found using the Kantorovich method of the partial separation of variables, since the conventional method of separating variables, which is usually employed for regular waveguides, in the given case is inapplicable. Using the obtained solution, it is possible to describe analytically the fields of smoothly deforming modes of a dielectric waveguide, their interrelation, and the dispersion relations between the distribution of the phase slowing coefficient and the local inclination of layers in the structure under consideration. The proposed method can also be used, in a quite broad range of wavelengths, for an analysis of analogous waveguide structures made of both dielectric and magnetic materials. © 2008 Pleiades Publishing, Ltd.